Lupus Disease: Scientists Found The Source Of The Autoimmune Disease “Lupus”.

Lupus Disease: “We found that there was a fundamental imbalance in the T cell types of patients with lupus,” said Dr. Deepak Rao, one of the study’s authors and a rheumatology specialist at Brigham and Women’s Hospital in Massachusetts.

It seems that the mystery behind one of the most common autoimmune diseases has finally been answered.

Researchers at Brigham and Women’s Hospital and Northwestern Medicine in the United States say they have discovered the main cause of the autoimmune disease Lupus, which affects hundreds of thousands of people in this country.

Lupus Disease, According to NBC, scientists have long suspected that hormones or genetics predispose people to lupus, and that the disease may be triggered by environmental factors, such as a previous viral infection or exposure to certain chemicals.

But now, a research published in the journal “Nature” by looking at the abnormalities in the immune system of people with lupus, identifies a clear path in how this disease occurs.

“We found that there was a fundamental imbalance in the T cell types of patients with lupus,” said Dr. Deepak Rao, one of the study’s authors and a rheumatology specialist at Brigham and Women’s Hospital in Massachusetts.

Lupus Disease, T cells are white blood cells that play a key role in the body’s immune response.

Lupus, also called systemic lupus erythematosus (SLE), is a chronic autoimmune disease in which the body’s immune system mistakenly attacks healthy cells.

Lupus Disease: Scientists Found The Source Of The Autoimmune

Lupus Disease, In this study, the researchers compared the blood samples of 19 people with lupus with the blood samples of healthy people and found that people with lupus had a large number of a type of T cell that damages healthy cells and a type of T cell associated with repair. and cell regeneration are very few.

At the center of this lack of balance is a protein called interferon, which helps the body defend itself against pathogens. Of course, scientists have known for years that people with lupus have high levels of type 1 interferon, but a new study links this to several negative factors.

Lupus Disease, First, too much type 1 interferon can limit or block the effect of a protein called the aryl hydrocarbon receptor, which regulates the body’s response to bacteria or environmental pollutants.

Blocking this receptor prevents the production of T cells that can help repair wounds on the skin, lungs, or intestines. It can also stimulate the production of those T cells that are involved in the creation of “autoantibodies”. Autoantibodies attack healthy cells and are characteristic of lupus.

Lupus Disease, Dr. Rao says this theory could explain the vast majority of lupus cases.

Lupus Disease, However, some experts have questioned the idea that there is a single explanation for all cases of lupus. According to them, since the symptoms of lupus are very diverse and the factors affecting it are numerous, it is very difficult to “find a main cause for this disease”.

Lupus Disease, According to the US Centers for Disease Control and Prevention, more than 200,000 people in the United States have lupus. Although the Lupus Foundation of America considers the number to be much higher and estimates approximately 1.5 million people.

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